İMÜ Nanolab yüksek lisans öğrencimiz Abdulbaki Belet'in başvurduğu "The Morphological and Mechanical Characterization of Collagen-Based Bioinks and Scaffolds" projesi H2020 Avrupa Nanoteknoloji Fonu tarafından desteklenmeye hak kazanmıştır. Fon kapsamında araştırmacımız, İtalya'da bulunan "The Department of Chemical Science & Materials Technology" alt yapısını kullanabilecektir.

Kendisini tebrik eder, başarılarının devamını dileriz.

Abstract

Tissue engineering has emerged to create scaffolds and grow cells in vitro. One of the methods used to produce scaffolds in tissue engineering is 3D bioprinting technology. 3D bioprinters are an emerging technology for fabricating in vitro scaffolds with controlled distribution of cells and biomaterials that can mimic living tissue in vivo. According to this method, a 3-dimensional structure is obtained by stacking a material by layers. This method facilitates the production of fast, accurate and reliable three-dimensional structures. Cell-loaded polymers, which are generally composed of biomaterials, biochemical molecules, living cells or their mixture, and materials used in the bioprinting process are called bioink. Hydrogels are used because they can better mimic soft tissue due to their high-water content. Collagen is the most applied biomaterials for tissue engineering structures (scaffolds). Since, collagen is the main component of the extracellular matrix (ECM). It is a structural protein that forms the basis of the connective tissue of the body and provides its strength and elasticity. Collagen has high biocompatibility, low immunogenicity and regulates cell adhesion, migration, and differentiation. It has a brous structure and is highly compatible with other materials. It is used as a bioink in 3D bioprinters, both alone and in combination with other polymers. However, since collagen scaffolds cannot maintain their structural form on their own, cross-linking agents are used. The most commonly used crosslinking agents in the literature are genipin, ribo avin and glutaraldehyde. In the literature, there are not any detailed studies to compare the crosslinked bioprinted collagen scaffolds by using these three cross-linking agents. In this proposed study, bioprinted collagen scaffolds that will be compared by means of structural integrity, morphology, and mechanical strengths, after crosslinking process.